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ProjectsCurrent Projects
A list of current projects for the Cardiac Imaging Group is shown below. A list of Completed Projects is also available.
Title:
ECHO CORE-LAB Analysis Agreement for the PROTECT-PACE Study
Duration:
2008 - 2012
Members:
Fundors:
Medtronic Inc.
Title:
Use of physiologic testing to optimize cardiac resynchronization therapy
Duration:
2008 - 2009
Members:
Marwick, T. H., Kaye, G. C., Jones, M.
Fundors:
National Heart Foundation
Title:
A multicenter, randomized, double-blind, placebo- and active-controlled study to assess the efficacy and tolerability of MK-6213 co-administered with atorvastatin in patients with...
Duration:
2008 - 2009
Members:
Fundors:
Merck, Sharp & Dohme
Title:
A phase II randomised controlled trial of atorvastatin therapy in intensive care patients with severe sepsis (NHMRC Project Grant administered by Monash University)
Duration:
2008 - 2009
Members:
Roberts, M. S., Kruger, P. S., Venkatesh, B., Bellomo, R., Kostner, K. M., Cooper, D. J.
Fundors:
Monash University
Title:
CCRE in Cardiovascular and Metabolic Disease
Duration:
2007 - 2012
Members:
Marwick, T. H., Prins, J. B., Macdonald, G. A., Isbel, N. M., Hegney, D. G., Stowasser, M., Coombes, J. S., Beller, E., Sharman, J., Hickman, I., O'Moore-Sullivan, T.
Fundors:
National Health And Medical Research Council
Abstract:
Metabolic disorders related to the modern lifestyle, including inactivity, obesity, the metabolic syndrome and type II diabetes, are responsible for a major proportion of the disease burden in Australia. Current treatment strategies are expensive and because they are directed at end-organ damage (heart failure, heart attacks etc), rather ineffective. This multispecialty, multidisciplinary group will undertake a series of unique studies aimed at understanding and preventing early cardiovascular complications of these metabolic conditions. Sensitive new cardiovascular imaging techniques will be used to detect preclinical abnormalities in the structure, function and metabolism of the heart and vasculature, facilitating the development of new strategies of exercise and lifestyle intervention to prevent these complications. While built on the successful current CCRE in Cardiovascular and Metabolic Disease, including multidisciplinary clinical research training, the new application involves major new directions in the interface between the liver and metabolic syndrome, and strategies for community-based prevention programs. The nursing intervention model, which will focus on workforce models of care, is especially important. The results of this study will provide information to address the need for different nursing models sought by the recent Productivity Commission Report.
Title:
Exertional dyspnoea with increased filling pressure - Mechanisms and treatment strategies
Duration:
2007 - 2009
Members:
Fundors:
National Health and Medical Research Council
Abstract:
Patients with early heart disease often present with shortness of breath with exercise, as myocardial reserve at that stage is usually sufficient to maintain normal function at rest . Indeed, much myocardial dysfunction may originate from the modern lifestyle, including inactivity, obesity, the metabolic syndrome and type II diabetes. The potential benefits of making a definitive early diagnosis are large, because it seems more likely that an impact can be made on the disease process (and therefore, outcome) than with late stage disease. Current treatment strategies are expensive and because they are directed at end-organ damage (heart failure, heart attacks etc), rather ineffective. This multispecialty, multidisciplinary group will undertake a series of unique studies aimed at identifying early cardiovascular disease. The strategy will involve detection of abnormal filling behaviour at stress echocardiography, with randomization into longterm and short-term trials to examine various therapeutic strategies. Sensitive new cardiovascular imaging techniques will be used to detect preclinical abnormalities in the structure and function of the heart and vasculature, facilitating a mechanistic understanding of the process of increasing filling pressure with exercise.
Title:
Australian Clinical Research (Postdoctoral) Training Fellowship Clinical application of arterial pressure waveform analyses: Role of exercise central blood pressure
Duration:
2006 - 2009
Members:
Fundors:
National Health and Medical Research Council
Title:
Detection and Management of Depression In General Practice Patients with Chronic Manifestations of Ischaemic Heart Disease
Duration:
2005 - 2009
Members:
Askew, D. A., Wilkinson, D., Dick, M. B., Schrader, G., Wade, T., Marwick, T. H., Scuffham, P. A., Jackson, C. L., Eckert, K., Stewart, S.
Fundors:
National Health And Medical Research Council
Title:
Clinical Study A5091043 - evaluation of the fixed combination toretracip/atorvastatin compared with atorvastatin alone on the occurence of major cardiovascular events.
Duration:
2004 - 2011
Members:
Fundors:
PharmaNet
Title:
Home Automatic external Defibrillator Trial (HAT)
Duration:
2003 - 2009
Members:
Fundors:
Seattle Institute for Cardiac Research
